| Serum-SalivaCorrelation | NA |
| Sensitivity | 2.5μg/mL |
| SampleTestVolume | 25μL |
| RecommendedCollectionVolume | 50μL* |
| SpecialConsiderations | SIgAis LocationDependent SIgAis FlowRateDependent (μg/mL) PassiveDrool isaPreferredCollectionMethod |
| CollectionProtocol | DownloadPDF |
SecretoryImmunoglobulinA(SIgA)isasubclassofImmunoglobulinA(IgA),an antibody thatplaysacriticalroleinmucosalimmunity. SIgAisthemainimmunoglobulinfoundinmucoussecretionsfromthetearglands,salivaryglands,mammaryglands,therespiratorysystem,thegenito-urinarytract,andthegastrointestinaltract.(1)SIgAisnotsynthesizedbymucosalepithelialcellsinthesestructuresorderivedfromblood. Instead,itisproducedbyB-lymphocytesadjacenttothemucosalcells,thentransportedthroughthecellinteriors,andreleasedintothesecretionsfromthecells.(2)SIgAplaysakeyroleinprotectingvulnerableareassuchastheoralcavity,lungs,andgutfrominvADIngpathogens.(1) DifferencesinSIgAlevelsinthesalivafromdifferentglandshavebeenobservedinhumans,withthehighestlevelsfoundintheminorsalivaglands.(2,3) SIgAexhibitsadiurnalrhythm,decreasingfromthehighestlevelsinthemorningtothelowestintheevening.(4)
LevelsofSIgAinsalivavaryinresponsetophysicalandpsychologicalstressthroughinteractionswiththeautonomicnervoussystem.(5,6) SIgAlevelsinsalivaareaffectedbyflowrates,withconcentrationsnormallydecreasingasflowratesincrease. MeasurementofflowratesisadvisableinordertoexpressSIgAsecretionasafunctionoftime.(6)
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