
Serum-SalivaCorrelation | NA |
Sensitivity | 10pg/mL |
SampleTestVolume | 50μL |
RecommendedCollectionVolume | 125μL* |
SpecialConsiderations | PassiveDrool isaPreferredCollectionMethod CRPis LocationDependent |
CollectionProtocol | DownloadPDF |
C-ReactiveProtein(CRP)isanacutephaseproteinproducedintheliver. SerumCRPmeasurementsarewidelyusedasabio-Markerofinflammationinthebody. ElevatedlevelsofserumCRPhavebeentiedtoincreasedriskforheartdisease,hypertension,stroke,andotherconditionsrelatedtoinflammation,suchasdiabetesandautoimmunedisorders.(1,2,3,4,5,6,7,8,9) TherelationshipbetweenserumandsalivarylevelsofCRPisnotwellunderstood. SalivaryCRPlevelshavebeenfoundtobehigherinchildrenwithallergicasthma,andinpigswithrespiratoryviralinfections.(10,11)Inanunpublishedstudy,sickpeopleadmittedtoahospitalhadaveragesalivaryCRPlevels25timeshigherthanhealthypeople.(12)SalivaryCRPmaylargelyreflectlocalinflammationinthemouth,butsomeserumCRPcanentersalivathroughgingivaltissues,especiallyifperiodontaldiseaseispresent.(13,14) OngoingresearchisinvestigatingthepossibilitythatsalivaryCRPcanbeusedtomonitorinflammationinotherpartsofthebody.(15,16,17,18,19,20)
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- DuClos,T.W.Editorial:C-reactiveproteinasaregulatorofautoimmunityandinflammation.(2003).ArthritisRheum,48(6),1475-77.
- Krasteva,A.,Perenovska,P.,Ivanova,A.,etal.(2010). Alterationinsalivarycomponentsofchildrenwithallergicasthma. BiotechnologyBiotehnologicalEquipment,24(2),1866-69.
- Gutiérrez,A.M.,Martínez-Subiela,S.,Soler,L.,etal.(2009). UseofsalivaforhaptoglobinandC-reactiveproteinquantificationsinporcinerespiratoryandreproductivesyndromeaffectedpigsinfieldconditions. VetImmunolImmunopathol,132(2-4),218-23.
- salimetricsinternaldata.
- Giannobile,W.V.,Beikler,T.,Kinney,J.S.,etal.(2009).Salivaasadiagnostictoolforperiodontaldisease:Currentstateandfuturedirections. Periodontol2000,50,52-64.
- Higashi,Y.,Goto,C.,Jitsuiki,D.,etal.(2008). Periodontalinfectionisassociatedwithendothelialdysfunctioninhealthysubjectsandhypertensivepatients. Hypertension,51(2),446-53.
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- Floriano,P.N.,Christodoulides,N.,Miller,C.S.,etal.(2009).Useofsaliva-basednano-biochiptestsforacutemyodardialinfarctionatthepointofcare:Afeasibilitystudy. ClinChem,55(8),1530-38.
- Gómez-Laguna,J.Gutiérrez,A.,Pallarés,F.J.,etal.(2010).HaptoglobinandC-reactiveproteinasbiomarkersintheserum,salivaandmeatjuiceofpigsexperimentallyinfectedwithporcinereproductiveandrespiratorysyndromevirus. VetJ,185(1),83-7.
- Gutiérrez,A.M.,Martínez-Subiela,S.,Eckersall,P.D.,Cerón,J.J.(2008).C-reactiveproteinquantificationinporcinesaliva:Aminimallyinvasivetestforpighealthmonitoring. VetJ,181(3),261-5.
- Tonetti,M.S.,D’Aiuto,F.,Nibali,L.,etal.(2007).Treatmentofperiodontitisandendothelialfunction.NEnglJMed,356(9),911-20.
- D’Aiuto,F.,Ready,D.,Tonetti,M.S.(2004).PeriodontaldiseaseandC-reactiveprotein-associatedcardiovascularrisk.JPeriodontRes,39(4),236-41.